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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T9805	BAY 2666605		PDE
	BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.		PDE
T24730	Roslin 2 bromide	Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK , p53
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects.		FAK , p53
T1801	SR9243		Liver X Receptor
	SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.		Liver X Receptor
T36646	Trastuzumab deruxtecan	DS-8201a,VRN-101099,DS 8201,T-DXd	Others
	Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gas...		Others
T72064	TASK-1-IN-1		Potassium Channel
	TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) (IC50: 148 nM).TASK-1-IN-1 has a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM.TASK-1-IN-1 has anticancer effects.		Potassium Channel
T71703L	Isomer-Turosteride	Isomer-Turosteride(Isomer-137099-09-3)	Reductase
	Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to ...		Reductase
T26285	TPMP-I-2	TPMP-I 2,TPMP-I2
	TPMP-I-2 has an anticancer effect of immunotoxins.
T62124	Anticancer agent 80
	Anticancer agent 80 (Compound 3c) is an anticancer agent that exhibits a significant dark toxic effect on T47-D (IC50: 10.14 μM).
T15262	Vactosertib Hydrochloride	TEW-7197 Hydrochloride,EW-7197 Hydrochloride	ALK
	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50...		ALK
T63599	Anticancer agent 54
	Anticancer agent 54 is an effective anticancer agent whose anticancer activity depends on DNA embedding and ROS generation. Anticancer agent 54 has an anti-proliferative effect by blocking the cell cycle in G0/G1 phase a...
T63671	Anticancer agent 60
	Anticancer agent 60 showed anti-proliferative effect on human HepG2 cells with an IC50 value of 4.13 μM. Anticancer agent 60 exhibited anti-tumor activity in a human HepG2 xenograft mouse model.
T78016	Angiopep-2 hydrochloride
	Angiopep-2 hydrochloride is a brain-targeting peptide vector. Conjugating anticancer agents to Angiopep-2 may enhance their therapeutic effect against brain cancer [1].
T61728	MY-875
	MY-875 is a potent microtubulin polymerization inhibitor that competes at colchicine binding sites, exhibiting an IC50 value of 0.92 μM. It effectively suppresses microtubulin polymerization, exerting its inhibitory effe...
T78768	HDAC6-IN-16		HDAC
	HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing...		HDAC
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 is a BCR-ABLL inhibitor that exhibits anticancer activity.BCR-ABL-IN-4 has an inhibitory effect on cancer cell growth and is able to act on K562 cells (IC50: 0.67 nM) and BCR-ABL T315I-transfected Ba/F3 cell...
T60731	Mitobronitol
	Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol. Mitobronitol is an anticancer agent classified as an alkylating agent. Mitobronitol shows myelosuppression effect that significantly reduced risk for se...
T62521	A2AAR/HDAC-IN-1
	A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.
T71361	CHS-828 nicotinate
	CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting ...
T73255	Akt1-IN-1
	Akt1-IN-1 is a potent and selective inhibitor of Akt1, demonstrating an IC50 of 18.79 nM in MIA PaCa-2 cells, indicating its high efficacy in inhibiting this specific kinase. Notably, it shows no significant teratogenici...
T63823	K20
	K20 is a potent and selective inhibitor of KRas G12C (IC50: 1.16 nM). In H358 cells, K20 has an anticancer effect with an IC50 value of 0.78 μM. K20 inhibits the growth of NCI-H358 tumor cells (TGI: 41%) without signific...
T61961	Pyruvate Carboxylase-IN-2
	Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC). In cell lysate-based and cell-based PC activity assays, Pyruvate Carbo...
T79322	Antiproliferative agent-30
	Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It...
T78608	Anticancer agent 164		Apoptosis
	CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosph...		Apoptosis
T36844	Inostamycin A
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)...

Compounds

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: Liver X Receptor

Trastuzumab deruxtecan

T36646

Synonym: DS-8201a,VRN-101099,DS 8201,T-DXd

Target: Potassium Channel

Isomer-Turosteride

T71703L

Synonym: Isomer-Turosteride(Isomer-137099-09-3)

Target: Reductase

TPMP-I-2

T26285

Synonym: TPMP-I 2,TPMP-I2

Target:

Anticancer agent 80

T62124

Synonym:

Target:

Vactosertib Hydrochloride

T15262

Synonym: TEW-7197 Hydrochloride,EW-7197 Hydrochloride

Target: ALK

Anticancer agent 54

T63599

Synonym:

Target:

Anticancer agent 60

T63671

Synonym:

Target:

Angiopep-2 hydrochloride

Pyruvate Carboxylase-IN-2

T61961

Synonym:

Target:

Antiproliferative agent-30

T79322

Synonym:

Target:

Anticancer agent 164

カタログ番号	製品名	別名	ターゲット
TN7060	Methyl oleanonate		PPAR
	3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.		PPAR
T3S1196	Mogroside IV		Others
	Mogrosides IV is a sweet minor cucurbitane glycoside, it exhibits maltase inhibitory effect(IC50 : 10 mM), and with antioxidant, antidiabetic and anticancer activities.		Others
T7441	Cuminaldehyde	Cuminic aldehyde,Cuminal	Endogenous Metabolite
	Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essenti...		Endogenous Metabolite
T10390	Asperphenamate		Others , Antifungal
	Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.		Others , Antifungal
T5724	Neogambogic acid	neo-gambogic acid	Apoptosis , Others , Antibacterial
	Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li...		Apoptosis , Others , Antibacterial
TN1727	Helichrysetin		Apoptosis , HIV Protease
	Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.		Apoptosis , HIV Protease
T5S1285	(+)-(3R,8S)-Falcarindiol	Falcarindiol	Others
	1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov...		Others
T3339	Sophoridine	5-Epidihydrosophocarpine,Dihydro-5-episophocarpine	Apoptosis , Topoisomerase
	Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity ...		Apoptosis , Topoisomerase
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T3S0081	Oxypeucedanin	(+-)-Oxypeucedanin,Oxypeucadanin	Potassium Channel
	1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke...		Potassium Channel
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T2S1865	Octyl gallate	Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8	Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV
	1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ...
T1033L	Monensin	Elancoban,Rumensin
	Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with d...
TN4695	Odorine		Others
	Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing t...		Others
TMA0424	Martynoside		ROS
	Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the me...		ROS
TN5264	Xanthoxyletin		TNF , NOS , ROS , COX , Antifection
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can...		TNF , NOS , ROS , COX , Antifection
TN5243	Vitexilactone		NADPH-oxidase , HIV Protease , Antifection
	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal ...		NADPH-oxidase , HIV Protease , Antifection
TN4223	Homopterocarpin		Antifection
	Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribu...		Antifection

天然物製品

Synonym: Cuminic aldehyde,Cuminal

Target: Endogenous Metabolite

Asperphenamate

T10390

Synonym:

Target: Others, Antifungal

Neogambogic acid

T5724

Synonym: neo-gambogic acid

Target: Apoptosis, Others, Antibacterial

Helichrysetin

TN1727

Synonym:

Target: Apoptosis, HIV Protease

(+)-(3R,8S)-Falcarindiol

T5S1285

Synonym: Falcarindiol

Target: Others

Sophoridine

T3339

Synonym: 5-Epidihydrosophocarpine,Dihydro-5-episophocarpine

Target: Apoptosis, Topoisomerase

Icaritin

T3398

Synonym: Anhydroicaritin,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Oxypeucedanin

T3S0081

Synonym: (+-)-Oxypeucedanin,Oxypeucadanin

Target: Potassium Channel

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Octyl gallate

T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Monensin

T1033L

Synonym: Elancoban,Rumensin

Target: TNF, NOS, ROS, COX, Antifection

Vitexilactone

TN5243

Synonym:

Target: NADPH-oxidase, HIV Protease, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04644	PDGFB Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-02395	PDGFB Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293 Cells
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-05076	PDGFB Protein, Canine, Recombinant (His)	Canine	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-04877	PDGFB Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-05077	PDGFB Protein, Rhesus, Recombinant (His)	Rhesus	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...

PDGFB Protein, Human, Recombinant (His)

TMPY-04644

Species: Human

Expression System: P. pastoris (Yeast)

PDGFB Protein, Cynomolgus, Recombinant (mFc)

TMPY-02395

Species: Cynomolgus

Expression System: HEK293 Cells

PDGFB Protein, Canine, Recombinant (His)

TMPY-05076

Species: Canine

Expression System: P. pastoris (Yeast)

PDGFB Protein, Mouse, Recombinant (His)

TMPY-04877

Species: Mouse

Expression System: P. pastoris (Yeast)

PDGFB Protein, Rhesus, Recombinant (His)

TMPY-05077

Species: Rhesus

Expression System: P. pastoris (Yeast)

カタログ番号	製品名
L1110	Microtubule-Targeted Compound Library	142 compounds
	A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS;
L6820	Tobacco Monomer Library	747 compounds

ライブラリー

Microtubule-Targeted Compound Library

L1110

Compounds: 142

Tobacco Monomer Library

L6820

Compounds: 747